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Krysiak-Zielonka, 2024: Regeneration von Knochen- und Knorpelgewebe – Neue Behandlungs- und Rehabilitationsstrategien, Ortop Traumatol Rehabil, 26(5), 225–232
Regeneration of bone and cartilage tissues is a key area of research and practice in sports medicine and orthopedics. Modern technologies, integrating traditional methods with innovative solutions, open new perspectives in therapy and improvement of patients’ quality of life. Examples of such methods and their clinical applications confirm the dynamic development of this field of medicine, which gives hope for achieving more satisfactory therapeutic outcomes in the future. Nuclear Magnetic Resonance Therapy (NMRT), also known as MBST®, is an innovative therapeutic method that is gaining popularity in the treatment of musculoskeletal disorders, including bone and cartilage regeneration. This method is an answer to the growing demand for effective and non-invasive methods of treating musculoskeletal conditions. Clinical trials conducted over the last 10 years provide ample evidence for the effectiveness of NMRT in the treatment of musculoskeletal conditions. NMRT is used to treat both chronic and acute diseases such as arthrosis and osteoporosis. Thanks to its properties, it focuses on the source of the problem, and not only on relieving the symptoms. An additional advantage is that no side effects have been demonstrated to date. Magnetic resonance therapy can be used as an adjunct to traditional treatments. Thanks to the ability to stimulate regenerative processes at the cellular level, it significantly accelerates the process of returning to full fitness. This article aims to discuss the processes of bone and cartilage tissue regeneration in response to nuclear magnetic resonance therapy (NMRT), present the results of clinical trials and therapeutic guidelines against the background of other treatment methods.
Žnidarič, Z. Kozinc, D. Škrinjar, 2023: Potential of molecular biophysical stimulation therapy in chronic musculoskeletal disorders: a narrative review, Eur J Transl Myol, 33(4), 11894
Current treatment of chronic musculoskeletal diseases does not give sufficient results despite the implementation of novel drugs and techniques in orthopaedics and physical therapy. For instance, osteoporosis treatment is currently mainly limited to drug application, while the goal of osteoarthritis treatment is to mitigate pain symptoms through physical therapy. The main therapeutic principle in the management of osteoporosis is not only to increase bone mass, but also to improve bone and the cartilage quality, which depends on the biomechanical balance. Therefore, there is a strong demand for advanced technologies that would safely and non-invasively accelerate cartilage regeneration and improve bone density. Ten years ago, a new state-of-the-art technology – “Molecular biophysical stimulation therapy (MBST)”, specifically nuclear magnetic resonance therapy, emerged on the medical technology market and until now, it has shown successful results in the conservative treatment of musculoskeletal disorders, including back pain. The aim of this review is to provide an integrated, synthesized overview of the current evidence of efficacy of MBST for managing chronic musculoskeletal disorders.
In conclusion, new therapeutic interventions are of utmost importance in providing long-term benefits for patients with musculoskeletal disorders, such as OA, OP and CBP.
It is generally known that interventions should firstly comprise non-invasive and if possible non-pharmacological interventions, with provoking positive effects on bone cells, soft tissue, pain reduction, evolving normal joint range of motion and inducing normal function. MBST is a non-invasive procedure that was derived from the MRI and employs the same physical principle as MRI machines, but with significantly weaker electromagnetic fields and radio frequencies. It was found that MBST possess several positive in vitro effects, such as histamine-induced calcium response, activity of MAP kinases, cellular production and IL-1β reduction in ATP.
This procedure is beneficial in bone fractures, soft tissue impairments such as tendon, ligament and muscle damage or pain, while also beneficial in patients with neurological impairments due to nerve injury and patients with OA and OP. Furthermore, clinical studies show that stimulation of the electromagnetic fields partially preserves osteoporotic bone mass, microstructures, and strength by impacting anabolic activities of the skeletal system.
K. Schmidt, J. E. Debess, & L. Møller, 2021: Magnetic resonance therapy in the treatment of osteoarthritis: A scoping review. Radiography, 27(3), 968–975
Objectives: To primarily assess the existing literature about Magnetic Resonance Therapy (MRT) or Molecular Biophysical Stimulation Therapy (MBST) in the treatment of patients with osteoarthritis (OA). The scoping review question was: What has been reported about MRT or MBST concerning treatment of patients with OA?
Key findings: The applied treatment program consisted of one hour daily treatment for patients in all the included studies. In terms of duration of treatment, four studies suggested treatment for nine consecutive days, two for five days and one study reported treatment on weekdays for two weeks. Six of the studies investigated the effect of MRT on the knee and one study for finger, ankle, and hip, respectively. Consensus across studies was that MRT had a positive, almost always significant, effect. Six out of the seven studies had subjective outcome measurements such as pain, quality of life and joint function, which were measured through self-reported questionnaires. One study combined ultrasonography with Magnetic Resonance Imaging (MRI) to evaluate structural joint changes. This evaluation was performed by a radiologist. One study used objective measurement of cartilage thickness through a minimal distance algorithm. All tests used MBST-systems.
Conclusion: This scoping review showed that there seems to be a beneficial effect of MRT in the treatment of patients with OA in relation to improvement in pain, joint function, and quality of life. However, more robust research and further evaluation of MRT are needed.
Implications for practice: Treating patients diagnosed with OA with MRT for one hour for five to ten days seemed to improve pain, joint function, quality of life as well as regeneration of cartilage. However, limitations of the included studies in this scoping review, such as a general lack of control groups, low sample sizes, lack of control for confounding factors such as medication, calls for more robust research with stronger study designs.
Lim Ee Hua & Yoon Kam Ho, 2020: Clinical Utility of Molecular Biophysical Stimulation Magnetic Resonance Therapy As A Novel Treatment of Symptomatic Knee Osteoarthritis in 111 Asian Patients: An Initial Experience, Poster presentation Korean Congress of Rheumatism, October 21 – 23, 2020
111 patients with knee osteoarthritis who underwent 5-7 sessions of MBST Open System 350 treatment from November 2018 to December 2019 were reviewed and analysed. 89 out of 111 (80.2%) patients had significantly decreased WOMAC scores after they done the MBST Open System 350 treatments sessions. 15 out of 111 (13.5%) patients had the same WOMAC scores, and 7 out of 111(6.3%) patients had worsening of their WOMAC scores. 80% of the patients felt that knees pain was significantly reduced and they can walk and stand with more confidences after using MBST Open System 350 for treating their knee osteoarthritis pain. MBST is a useful adjunct therapy for improving the pain and functions of the majority of the patients who suffers from OA knee. Its advantage lies in that it is a non-invasive, non-medication and safe therapeutic approach and is well received by the elderly patients who have multiple comorbidities and on polypharmacy.
Kitaev, 2017: Alternative «soft methods» in the therapy of degenerative diseases of joints, Trauma Surgery / Orthopaedics / Surgery, 06/2017, 2(6), 101–104
The therapeutic effect of the treatment of pain associated with osteoarthritis of the knee joints was evaluated with the use of the new MBST treatment system, which uses nuclear magnetic resonance as a basic principle in combination with soft manual techniques. The evaluation was performed on 116 patients with gonarthrosis. Assessment of pain was carried out using a visual-analog scale, the algo-functional Leken index and the need for NSAIDs. A marked reduction in the pain syndrome after the course of therapy is shown with a subsequent deepening of the analgesic effect for 6 months. The results of morphological changes in the form of restoration of cartilaginous tissue, as a long-term perspective, are demonstrated.
Kitaev & O. Plastinina, 2017: The concept of an integrative holistic approach in the rehabilitation of patients with degenerative diseases of the musculoskeletal system, Anthology of scientific papers from the interregional scientific-practical conference Rehabilitation and Prevention in Modern Medicine, Saratow, 143–148
The statistical evaluation of several clinical studies of 268 patients with degenerative spine and joint diseases treated with an integrative approach and MBST magnetic resonance therapy shows after one treatment cycle:
Kullich, J. Overbeck & H. U. Spiegel, 2013: One-year-survey with multicenter data of more than 4,500 patients with degenerative rheumatic diseases treated with therapeutic nuclear magnetic resonance, Journal of Back and Musculoskeletal Rehabilitation, 26 (2013), 93–104
Related publication:
Kullich, B. Steinecker & J. Overbeck, 2013: Long-term pain reduction after magnetic resonance treatment of various types of osteoarthritis, SCHMERZ Nachrichten, 4a
Background and objectives: Nuclear magnetic resonance (NMR) has been shown to stimulate repair processes and cartilage and to influence pain signalling. It represents an alternative therapy for patients suffering from osteoarthritis (OA). To prove the clinical success of this new therapeutical method, validated measuring parameters are important that are convincing for pain and function in a one-year-follow-up.
Methods: During the course of its application over the last 10 years, over 4,500 protocols of a one-year-follow-up have been collected to record the outcome of NMR therapy. This report reflects the outcome of NMR therapy on patients with the following degenerative rheumatic diseases: OA of the knee (n = 2.770), OA of the hip (n = 673), OA of the ankle joint (n = 420) and chronic low back pain (n = 655). Data were collected at baseline, 6-8 weeks and 6 and 12 months following NMR treatment.
Results: Pain was reduced significantly 6 weeks after NMR treatment in the cases of all four examined indications and stayed measurably reduced up to 6 and 12 months. The improvements in all three forms of pain (pain on load, pain on motion, pain at rest) following NMR treatment were around 21-50% on average.
Conclusions: Following therapy with NMR, patients with OA of all four types experienced a distinct improvement in their ability in functional parameters. Overall, the 10 years of a one-year-survey with multicenter data gathered on the effect of NMR therapy on patients verifiably proved its efficacy amongst patients with degenerative rheumatic diseases.
van Laack, A. Levers & M. Staat, 2011: Analysis of the Long-Term Effect of the MBST® Nuclear Magnetic Resonance Therapy on Gonarthrosis, Orthopädische Praxis, 11/2011, 47
Based on a questionnaire for patient-queries regarding pain-sensation and activity restrictions during everyday MBST® nuclear magnetic resonance therapy is studied in osteoarthritis of the knee. 39 patients, whose therapy dates back up to four years, participated in the study. In addition to an overall view, the success of this therapy is also analyzed regarding age, gender and physical activities. Overall, the study pointed out a sustained improvement in the patients’ local health-status with a significant pain-relief even after four years, but also with a slight increase in pain towards the end of that four-year period. There tends to be a more positive effect on women, on elderly or also on even non-sports-active patients which suggests a possible by daily (over)-stressing on the success of the therapy. An additional positive effect of the therapy on bone density is also conceivable, however this remains open.
Brockamp, 2009: Does MBST® magnetic resonance therapy have an effect on post-traumatic gonarthrosis in the rabbit model? 6 weeks trial. An experimental animal study, Inaugural dissertation University Hospital Münster, Clinic and Polyclinic for Trauma, Hand and Reconstructive Surgery
Related publication:
Jansen, S. P. Frey, J. Paletta & R. H. Meffert, 2011: Effects of low-energy NMR on posttraumatic osteoarthritis: observations in a rabbit model, Archives of Orthopaedic and Trauma Surgery, 11/2010, 131, 863–868
Introduction: In recent years, the use of electromagnetic fields has been increasingly examined for various clinical issues following positive results in the treatment of patients. Large-scale in-vivo and in-vitro studies have aimed to identify a mechanism of action in order to create a new therapeutic approach in the field of osteoarthritis. The aim of the present study was to find out whether the application of MBST® nuclear magnetic resonance has an effect on the morphology of cartilage in moderate gonarthrosis in an animal model.
Methods: In 12 male, adult, skeletally mature rabbits of the “New Zealand White” breed, the anterior cruciate ligament of both hind legs was surgically severed to induce moderate osteoarthritis over a period of 6 weeks. After these 6 weeks, the animals were randomized into two groups. The therapy group was treated for one hour per day on 7 consecutive days using the MBST® device from MedTec. The control group was kept under the same conditions, but the therapy device was not activated. After the animals were sacrificed, the knee joints were examined macroscopically and microscopically using various scores.
Results: Macroscopically, the animals in the therapy group showed a significantly lower result (p < 0.05) in three of four parameters assessed than the animals in the control group. Microscopic evaluation revealed no significant difference between the therapy and control groups.
Conclusion: An existing difference between the two compared groups suggests a possible influence of the MBST® therapy. Further studies are necessary to confirm this influence.
Kullich & M. Außerwinkler, 2008: Functional improvement in finger joint osteoarthritis with therapeutic use of nuclear magnetic resonance, Orthopädische Praxis, 6/2008, 44, 287–209
Because of the limited treatment possibilities for hand osteoarthritis, there is a need for assessment of new treatment strategies. Recent studies show that nuclear magnetic resonance (NMR) can stimulate repair processes in cartilage and can influence pain signalling transduction cascades; consequently, NMR may have therapeutic effects on osteoarthritis. 70 patients (aged 53 to 69) with osteoarthritis of the hand or finger joints were treated with NMR ( 9 x 1 h) double-blind, randomized and placebo controlled, and the effect was assessed over a period of 6 months. The treatment resulted in significant improvement in the physical function of the hand (QUABA score) after 9 days NMRT which persisted after 6 months. Conversely, these functions deteriorated in the placebo group. Similar results were observed for intensity and frequency of pain.
Fagerer & W. Kullich, 2007: Nuclear magnetic resonance as a new treatment option for osteoarthritis of the knee, Arzt & Praxis, 05/2007, 927, 180–182
Within the context of post-marketing surveillance with follow-up after 6 months, the therapeutic application of nuclear magnetic resonance was investigated in 32 patients with osteoarthritis of the knee and long-term symptoms. In order to document treatment outcome, a 10-point Visual Analogue Scale for pain (VAS), a specially-created score for frequency of pain, as well as the Lequesne index for knee disease were used before and immediately after therapy, and after a period of 6 months. Pain intensity and pain frequency were clearly improved as the result of the Nuclear Magnetic Resonance Therapy. Symptoms relating to pain and discomfort, and restricted movement in everyday life, as measured using the Lequesne index, were also markedly improved after treatment. The therapy appears to have a particularly good effect in patients with severe osteoarthritic knee pain. In some cases, the results of the treatment were still recognisable after 6 months, however there was a trend for the effect to diminish. In addition to cartilage regeneration, the mechanisms triggered by the Nuclear Magnetic Resonance Therapy and the resulting rapid short-term improvement in symptoms should be investigated further.
Auerbach & C. Melzer, 2003: Prospective Study in respect to the effectiveness of the MBST®-NuclearMagneticResonanceTherapy as used during the conservative therapy of Gonarthrosis
In summary, we consider MBST® magnetic resonance therapy to be a very useful, complementary therapy method with short treatment times for significantly affecting osteoarthritis-related complaints of the knee joint. The reduction of pain, improvement of joint function and reduction of joint stiffness in osteoarthritis of the knee has been prospectively proven over a period of 6 months. As an alternative to invasive procedures (surgery, injections), the absence of side effects, the ease operation and the significant therapeutic success – which steadily improved without follow-up treatment until the last time of data collection six months after the end of MBS therapy – are impressive. The extent to which a structural modification exists in addition to the symptom-modifying effect should be confirmed by further studies.
Klapsch, 2002: MBST – magnetic resonance therapy, Therapy option for degenerative and traumatic joint changes
During September 01, 2001 and December 31, 2002, treatments of 55 patients with a 5-hour therapy (34 knee joints, 11 ankle joints, 2 elbow joints, 2 rear feet, 6 hands) and 68 patients with a 9-hour therapy (52 knee joints, 7 ankle joints, 9 hands) for a peripheral joint were assessed prospectively with another check-up at least 6 weeks, on average 6.2 months after the end of treatment.
The results can currently certainly only be seen as a trend. The numbers of patients for each seperate diagnosis are too low. However, it is an extremely gratifying fact that the expectations of 74% of the patients were completely met, and partially in a further 15%. Only 11% did not experience any improvement by the treatment and were therefore not content. Taking into account an even more thorough approach regarding indication and diagnostics, it should be possible to reduce the percentage of dissatisfied patients to 4%. Under these conditions, my evaluation of this relatively new therapeutic option can only come to a positive conclusion.
Froböse, U. Eckey, M. Reiser, C. Glaser, F. Engelmeier, J. Assheuer & C. Breitgraf, 2000: Evaluation of the Effectiveness of Three-dimensional Pulsed Electromagnetic Fields of the MultiBioSignalTherapy on the Regeneration of Cartilage Structures, Orthopädische Praxis, 8/2000, 36, 510–515
Pulsed electromagnetic fields are being used as therapy for bone fractures tor a fairly long time. But there is not yet a scientific study available concerning the application in cartilagenous structures in vivo in human beings. In this study 14 patients with osteoarthritis of the knee (stage II and III according to Wirth) underwent a pulsed electromagnetic field therapy (appliance: MBST 1 of MedTec Medizintechnik GmbH) in nine successive sessions. The effectiveness of this intervention was assessed with the procedure according to Eckstein et al. (1998) which on the basis of magnetic resonance imaging allows a three-dimensional reconstruction and thus a quantitative analysis of the cancellous structures. The present results evidently indicate that positive adaptations of the cartilagenous structures occurred (thickness, volume, surface) which are speaking in favor, in the therapeutic procedure applied, for an effect of the complex PEMF technique. It is presumed that this mechanism is resulting tram an activation of intact and/or partly functioning cartilagenous cells as well as from an increase of the synthesis of collagen. It should, however, be taken into account that obviously a special characteristic feature of the PEMF technique is necessary to release such adaptations.
*This study was published shortly after the development of MBST when the therapy was as yet new and little known so it was tried to sort it into known categories of treatment. But MBST needs to be differentiated from PEMF and is an individual form of treatment which – in contrast to PEMF – does not use simple magnetic fields but generates magnetic resonance conditions.
K. Levchenko, I. V. Kitaev, O. V. Arleninova, A. V. Zareckos, G. A. Adamovič, A. A. Tixov, J. A. Cibrikova & A. V. Birjukova, 2017: MBST-Exposure Opportunities as a Monotherapy of Chronic Dorsalgia, Traumatoloy and Orthopedics, 2017, 13(3), 743–746
The aim: to analyze the clinical effect of MBST-exposure monotherapy, a magnetic resonance method, on the pain syndrome caused by degenerative dystrophic changes of vertebral column structures.
Material and Methods: 132 patients both male and female with cervical and lumbar dorsopathy were enrolled into the study. Treatment course included 9 sessions of 60 min. daily. MRI-results of corresponding spine regions and visual analogue pain intensity scale were used as assessment tools for treatment efficiency before, immediately after, 3, 6 and 12 months after MBST treatment.
Results: The objective results of structural transformation of pathological formations in vertebral motional segments correlated with significant decrease of pain syndrome at all stages of control tests.
Conclusion: MBST exposure is an effective method of non-invasive, notouch monotherapy for patients with chronic dorsalgia caused by degenerative dorsopathy.
V. Kutenev, K. K. Levchenko, I. V. Kitaev, A. V. Voljanskaja & V. G. Abakarova, 2017: Mbst-therapy as an effective method of treatment of patient of syndrome related to dorsopathy, Modern Medicine, Neurology / Rheumatology, Rehabilitation, 04/2017, 1(5), 3–6
An evaluation of the therapeutic effect of the treatment of pain syndrome associated with dorsopathy with the application of a new MBST treatment system using nuclear magnetic resonance as a principle has been carried out. The study was performed on 56 patients with severe pain associated with dorsopathy of lumbar or cervical localization. Treatment with this new apparatus of nuclear magnetic resonance therapy MBST was conducted for 1 hour for nine consecutive days. The assessment of pain was carried out using a visual analogue scale and showed a marked decrease in the pain syndrome after the course of therapy with the subsequent deepening of the analgesic effect for 3 months. The results of morphological changes in the form of regression of intervertebral disk extrusions in the long term are demonstrated.
The initial post-therapeutic assessment of the change in pain intensity using the 10-point visual analog scale showed significant relief in all types of pain: a) peak pain by 45%, b) average exertional pain by 38% and c) rest pain by 50%.
The trend towards further statistically significant pain relief was also observed three months after MBST therapy. Compared to the respective baseline, the patients’ peak pain was reduced by a further 70% and their average exertion pain by 66%, and the examination of pain at rest also showed a significant reduction in pain intensity of 98%.
Salfinger, G. Salomonowitz, K. M. Friedrich, J. Hahne, J. Holzapfel, M. Friedrich, 2015: Nuclear magnetic resonance therapy in lumbar disc herniation with lumbar radicular syndrome: effects of the intervention on pain intensity, health-related quality of life, disease-related disability, consumption of pain medication, duration of sick leave and MRI analysis, Eur Spine J, 10/2014, 24, 1296–1308
Purpose: The objective was to assess the effects of therapeutic nuclear magnetic resonance (tNMR) as a conservative treatment for lumbar radicular syndrome (LRS) in patients with lumbar disc herniation.
Methods: The prospective, randomised, double-blind, placebo-controlled trial included 94 patients, aged 20–60 years (44.79 ± 8.83), with LRS caused by lumbar disc herniation confirmed by MRI scans and with clinical signs of a radicular lesion without indication for surgical intervention. Treatment group (TG) and control group (CG) received standard non-surgical therapy. Additionally, the TG had seven sessions with the tNMR device with a magnetic flux density of 2.3 mT and a frequency of 85 kHz; the CG received 7 sham treatments. Outcome parameters were the treatment effect on pain intensity (Visual Analogue Scale—VAS), health-related quality of life (36-item Short Form Health Survey—SF-36), diseaserelated disability (Roland Morris Disability Questionnaire—RMDQ), pain medication intake, duration of sick leave and morphological changes assessed by MRI scan analysis.
Results: VAS scores improved significantly in both groups (p\0.000). Only in week 4, improvement in the TG significantly surpassed that of the CG (morning pain p = 0.011, evening pain = 0.001). In both groups, SF-36 scores reflected a significant amendment in the physical component score (p\0.000) and a significant deterioration in the mental component score (p\0.000). SF-36 scores did not differ significantly between groups. RMDQ showed a significant amelioration in both groups (TG and CG p\0.000), with a tendency to a superior benefit in the TG (p = 0.083). Patients in the TG recorded significantly fewer days of sick leave in month 3 after treatment (p = 0.026). MRI scan summary scores improved significantly in both groups (L4/5 p\0.000, L5/S1 p\0.001) and did not differ significantly between the groups.
Salomonowitz, H. Salfinger, J. Hahne, M. Friedrich, 2011: Impact of magnetic resonance therapy on sickness absence of patients with nerve root irritation following a lumbar disc problem, Z Orthop Unfall, 149(5), 575–581
Background: The prevalence of spinal symptoms in Western industrialised countries ranges up to 80 %. Back pain ranks second among the most common reasons to seek medical advice. The resulting financial burden on the health-care system is proportional to the subjectively experienced pain. The aim of the present study was to determine whether the use of magnetic resonance therapy alters the duration of sickness absence in patients with discogenic radiculopathy.
Patients and method: In a double-blind prospective randomised study, the use of magnetic resonance therapy for back pain in patients with discogenic radiculopathy was evaluated in the context of health economics. Patients aged 20 to 55 years with lumboischialgia and no indication for surgery were included in the study. The primary variable was the number of days of sickness absence in a study group before and after magnetic field therapy, and in a control group. The number of days of sickness absence was determined on the basis of a pain diary and by telephone inquiry.
Results: Patients who were treated with an activated magnetic resonance therapy device had significantly fewer days of sickness absence (p = 0.009) when evaluated by personal telephone calls. The duration of sickness absence before therapy was 14.7 days and that after therapy 5.8 days. In contrast, the days of sickness absence in the control group were 7.6 days before therapy and 13.8 days after therapy. The duration of symptoms was negatively correlated with the days of sickness absence. Patients who reported a burden at work had more days of sickness absence (8.3 days) than those with no burden at work (3.2 days). This correlation does not apply to familial burden. The cost-effectiveness analysis showed different degrees of compensation of the cost of magnetic resonance therapy, depending on the occupational group. Direct and indirect costs of magnetic resonance therapy were compensated by 16.9 fewer days of sickness absence among workers, 11.4 fewer days of sickness absence among employees, and 9.1 fewer days of sickness absence among civil servants.
Conclusion: Based on the number of days of sickness absence, the study confirmed that a relatively economical alternative technique is able to provide pain relief as well as benefit the health economy. Unemployed patients or patients who have submitted an application for a pension may be problematic because they may not wish to be pronounced healthy by their doctors.
Kullich, H. Schwann, J. Walcher & K. Machreich, 2006: The effect of MBST®-NuclearResonanceTherapy with a complex 3-dimensional electromagnetic nuclear resonance field on patients with Low Back Pain, Journal of Back and Musculoskeletal Rehabilitation, 11/2006, 19(2), 79-87
Related publication:
Kullich, H. Schwann, K. Machreich & M. Ausserwinkler, 2006: Additional Outcome Improvement in the Rehabilitation of Chronic Low Back Pain after Nuclear Resonance Therapy, Rheumatologica, 01/2006, 20, 7–12
A new treatment system using nuclear resonance as its active principle was applied, as an adjunct to a normal standardized physiotherapy programme. This novel NuclearResonanceTherapy (MBST® or MBS-Therapy) was applied for one hour on five successive days. The study was performed double blind, placebo-controlled and randomised on 62 rehabilitation patients suffering from chronic Low Back Pain at baseline, after one week and after 3 months. The pain measurements using the Visual Analogue Scale (VAS) showed a distinct reduction of pain after active MBS’J® and placebo. The Roland & Morris Disability lndex (RM) total score also improved significantly in both groups, but the improvement was more distinct in MBST® patients compared to placebo. After three months, the positive effect of MBST® on the RM total score was still significant (p < 0.00001) whereas this was not the case for the placebo-treatment.
The significant improvement in the MBST®-group was primarily evident in the RM-questions regarding incapacities caused by Low Back Pain, particularly sleeping problems, fatigue, bending ability, and the time required to get dressed. NuclearResonanceTherapy as a complementary treatment can improve the outcome obtained by inpatient rehabilitation programmes after 3 months.
Krpan, W. Kullich, 2017: Nuclear magnetic resonance therapy (MBST) in the treatment of osteoporosis. Case report study, Clinical cases in Mineral and Bone Metabolism, 2017, 14(2), 235–238
Objectives: To demonstrate the long-term effects of the therapeutic use of nuclear magnetic resonance (NMR) on bone mineral density (BMD) parameters in patients with osteoporosis.
Methods: We enrolled 103 patients aged between 45 and 89 years who had osteoporosis with a T-score of bone mineral density less than -2.5. All patients received an osteoporosis treatment with low field nuclear magnetic resonance using a special NMR device (MBST, MedTec, Germany) for one hour per day on 10 consecutive days. At baseline and 12 months after NMR treatment the BMD was measured by DEXA. Additionally, the levels of the bone turnover markers osteocalcin and bone crosslaps (b-CTX; crosslinked telopeptides of collagen 1) were measured by immunoassays.
Results: BMD and serum levels of osteocalcin increased significantly from baseline to 12 months. b-CTX remained stable.
Conclusions: Under therapeutically use of NMR-Therapy, BMD-parameters increased during 12 months after a treatment block (10 x 1h). Therefore, NMR-Therapy can be considered a useful alternative or supplement to medical therapy in patients with osteoporosis.
Krpan, B. Stritzinger, I. Lukenda, J. Overbeck, W. Kullich, 2015: Non-pharmacological treatment of osteoporosis with Nuclear Magnetic Resonance Therapy (NMR-Therapy), Periodicum Biologorum, 2015, 117, 1, 161–165
Related publication:
Kullich, I. Lukenda, B. Stritzinger, J. Overbeck, D. Krpan, 2016: Therapeutic application of magnetic resonance for osteoporosis, Ber. Nat.-med. Ver. Salzburg, 2016, 18, 7–17
Objectives: To demonstrate the long-term effects of the therapeutic use of nuclear magnetic resonance (NMR) on bone mineral density (BMD) parameters in patients with osteoporosis.
Methods: We enrolled 103 patients aged between 45 and 89 years who had osteoporosis with a T-score of bone mineral density less than -2.5. All patients received an osteoporosis treatment with low field nuclear magnetic resonance using a special NMR device (MBST, MedTec, Germany) for one hour per day on 10 consecutive days. At baseline and 12 months after NMR treatment the BMD was measured by DEXA. Additionally, the levels of the bone turnover markers osteocalcin and bone crosslaps (b-CTX; crosslinked telopeptides of collagen 1) were measured by immunoassays.
Results: BMD and serum levels of osteocalcin increased significantly from baseline to 12 months. b-CTX remained stable.
Conclusions: Under therapeutically use of NMR-Therapy, BMD-parameters increased during 12 months after a treatment block (10 x 1h). Therefore, NMR-Therapy can be considered a useful alternative or supplement to medical therapy in patients with osteoporosis.
Handschuh, C. Melzer, 2008: The treatment of osteoporosis with MBST® Magnetic Resonance Therapy, ORTHODOC, 05/2008, 02, 1–4
MBST® Magnetic Resonance Therapy is an innovative and easy to use treatment procedure, that is not associated with any side effects, and that will stabilize and increase bone density, reduce symptoms, and increase the overall well-being of patients in the short-term when used in conjunction with a basic supplementation therapy of calcium and Vitamin D3. It does not have any effect on the bone density of patients undergoing long-term treatment with bisphosphonates and SERMs. MBST® Magnetic Resonance Therapy also proves an interesting treatment option with respect to the costs associated with its use as opposed to those associated with the long-term medication-based treatment of osteoporosis. Since there is not, at present, any comparative data nor any data on the long-term use of MBST® Magnetic Resonance Therapy, its long-term effects and benefits in the conservative treatment of osteoporosis will yet have to be investigated.
Overbeck, A. Urban, G. Gerhardt, J. Gerhardt, 2003: Scientific Evaluation of the Effectiveness of wholebody MBST®-NuclearMagneticResonanceTherapy for treatment of Osteoporosis
27 patients whose degenerations (caused by Osteoporosis) were diagnosed after a bone density measurement (Osteo-CT and DEXA-measuring method) were treated in the practices by MBST®-NuclearMagneticResonanceTherapy from May 2002 to October 2003. The therapy was conducted within 2 weeks in 10 one hour treatment sessions on consecutive days.
The following blood values were measured and evaluated in the laboratories during the 10-days therapy: Calcitonin, Phosphate, Calcium, Creatinine, Parathormon, Desoxipyridivolin in the second morning urine. During the MBST-Therapy a daily evaluation protocol of the pain situation was written by a visual analog-scale (ranging from 0 to 10 points): Pain while resting, Pain in motion, Maximum pain, measurements of the bone density were performed within a time period of 6 months.
If we compare the basic values of 24 patients, measured before start of the therapy, with the measuring results achieved 6 months after the MBST®-NuclearMagneticResonanceTherapy (for whole-body treatment of Osteoporosis), we can realize a clearly positive modification of the bone density.
Positive modification of the bone density values evidenced within a time period of 6 months: Increase of T-values 4,15 % up to 33,90 %, Increase of Z-values 3,57 % up to 72,46 %, Increase of mineral salt value 1,00 % up to 35,40 %, Increase of BMD-value 1,51 % up to 9,08 %.
Klapsch, 2003: Prospective casestudy of the active principle of MBST Nuclear Magnetic Resonance Therapy as a possible whole-body osteoporosis treatment without medication
Following the result of this prospective investigation, MBST® Magnetic Resonance Therapy apparently has a positive effect on the degree of human bone mineralization. In more than 60% of the patients examined an increase in bone density by an average of 28% could be recorded. The subjectively felt pain intensity could be reduced highly significantly, the pain frequency could be reduced drastically. The treatment was done as a whole-body therapy in 10 sessions at one hour each. The reasons for the success of the treatment have not yet been clarified and are probably multifactorial. Controlled studies should be initiated in order to verify the therapeutic success in the treatment of osteoporosis in a larger number of probands and under scientific conditions.
G. Baños Marín, A. E. Fidalgo, A. B. Moreno Cañada, A. C. Rueda Molina, 2021: Nerve Card: the Function Card. Case Report Study, Clinica Luis Banos
If there is an integrative tissue that interconnects all the elements involved in the human body, that is the nerve tissue. Taking as reference the very good results obtained with MBST technology applied to a wide variety of pathologies (osteoarthritis, bone edema, fractures of various structures, …) we began to think about the therapeutic opportunities that a card that acted on the nervous system could offer us and, therefore, we could apply it in direct pathology of a nerve.
The response was so good in terms of improved pain and function, that we started to expand the indications, and our surprise was growing because of the great result of the card. With date 22-1-2021, we have used with 162 patients the nerve card and 21 pathologies that we will describe below and, honestly, the results have exceeded our expectations.
After a detailed evaluation of the treated patients, we can say that the nerve card is a very versatile card, which can be used for peripheral neuropathy (such as a sciatica) a systemic injury of the nervous system (Multiple Sclerosis) a disorder in the modulation of pain (Central Pain) a spinal injury, rheumatism (ankylosingpolyspondylitis), a section of a peripheral nerve, a sequelae much more than we expected at first. acting on the nervous system through the stimulus of MBST technology we can improve pathological and regenerative processes very varied. In general, the pain sometimes improves a lot so it has excited us the most is to see how it improves function.
Observational study regarding the application of MBST magnetic resonance therapy for wound healing of different kinds of wounds, Wundheilungszentrum Boppard, 2023
This controlled, non-interventional observational study includes 2 groups. The group definition is done by the Wundheilungszentrum. In the frame of clinical routine, one group is treated additional with an MBST therapy within its intended use, the control group does not receive additional treatment. Patients were observed for a maximum of 10 days and the patients in the MBST group received MBST therapy on consecutive days.
Primary variable of this observational study was faster wound healing in patients with chronic wounds treated with MBST® OSTEO∙SPIN versus the control group of patients with chronic wounds not treated with MBST® OSTEO∙SPIN.
This was shown by: wound size, wound condition, wound borders and wound environment, if possible exsudate status during change of dressing.
This evaluation of the observational study was done with validated data until and including 07.03.2023. At this time, there were 42 data sets. The age of the treated chronic wounds was on average 210 days. Wound size was reduced in both study arms over the course of treatment: in the intervention group by 26.09 % and in the control group by 8.17 %. Pain intensity was reduced over the course of treatment in both study arms. The percentual pain reduction, however, was higher in the intervention group compared to the control group. The resulting absolute average pain reduction of 2.333 points is also superior to the 0.368 points in the control group.
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