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Huels, O. Harms, D. Keim, K. Rohn & M. Fehret, 2020: Treatment of the Clinical Symptoms of Osteoarthritis in the Elbow Joints of Dogs Using Nuclear Magnetic Resonance Therapy: A Randomized, Double-Blinded Trial, Frontiers in Veterinary Sciences, 11/2020, 7,
Objectives: To evaluate the effects of nuclear magnetic resonance therapy (MBST®) on the clinical symptoms of osteoarthritis (OA) in the elbow joints of dogs.
Methods: In this double-blind study, 28 dogs with lameness caused by OA in the elbow joint were randomly allocated to two groups: 14 dogs received nuclear magnetic resonance (NMR) therapy [treatment group (TG)], and 14 dogs received a placebo [placebo group (PG)] over a period of 7 consecutive days. Visual and objective gait analyses were performed before treatment (M1) and at 3 (M2) and 6 months (M3) after treatment. At M2 and M3 Symmetry indices (SI) of the peak vertical force (PVFz) and the vertical impulse (IFz), lameness scores, and pain scores were compared with their values at M1 to calculate the overall treatment effectiveness (OTE) score. We also documented additional pain medication and medical physiotherapy during the time of study. Finally, we measured the range of motion (ROM) in order to evaluate the functional development of the joint.
Results: The median OTE score of dogs in the TG indicates no change after 3 month and was improved after 6 months of treatment. There was an improvement of the median OTE score of dogs in the PG after 3 months of treatment. Further, the OTE scores of dogs in the PG were actually worse after 6 months.
Nevertheless, there were no significance differences in SIPVFz, SIIFz, ROM, and lameness- and pain scores between the TG and PG at M1, M2, and M3. When considering all collected parameters (excluding the ROM) to calculate the OTE, no significant difference between groups was measurable for the OTE.
Conclusion: There was a positive effect of NMR therapy (MBST®) on the treatment of OA in dogs. However, future studies should investigate the mechanisms underlying NMR therapy and the pathophysiology of OA to provide optimal treatments for patients.
Clinical Significance: Our results demonstrated that the response to NMR treatment was individualized for each dog. As an integral way of treating dogs with chronic OA, NMR therapy may be an alternative therapeutic approach to support traditional medications.
Bockstahler, M. Müller & K. Wittek, 2014: MultiBiosignalTherapy (MBST®) in the treatment of osteoarthritis-attributed lameness, Newsletter of Universitätsklinik für Kleintiere, Vetmeduni Vienna, 01/2014
Multi BiosignalTherapy (MBST®) is based on the physical principle of nuclear magnetic resonance, using weaker fields and lower frequencies than those used in diagnostic imaging. The effects are said to range from stimulating the regenerative capacity and new formation of cartilage cells to reducing osteoarthritis-related pain and improving joint function. In a double-blind randomized study with dogs suffering from osteoarthritis at the Vetmeduni Vienna, positive effects on lameness were demonstrated. MBST® therefore offers itself as a complementary form of therapy – a device is now available at the Vetmeduni Vienna. Nine one-hour treatments are carried out on consecutive days (with a break at the weekend).
Jansen, S. P. Frey, J. Paletta & R. H. Meffert, 2011: Effects of low-energy NMR on post-traumatic osteoarthritis: observations in a rabbit model, Archives of Orthopaedic and Trauma Surgery, 11/2010, 131, 863–868
OBJECTIVE: To investigate the potential positive effect of low-energy nuclear magnetic resonance (NMR) on cartilage in moderate to severe post-traumatic osteoarthritis in rabbits using a macroscopic and histological classification system.
SETUP: After transection of the anterior cruciate ligament of both knees in 24 skeletally mature white New Zealand rabbits, different stages of osteoarthritis (OA) were observed 6 and 12 weeks postoperatively. The animals were randomly divided into four groups: Group 1 (eight animals) was treated with NMR (magnetic field: 20-40 G, interference field: 2.35 mT, 100 kHz; MBST device, MedTec, Germany) for one hour on seven consecutive days after 6 weeks. Group 2 was treated according to the same pattern after 12 weeks. The sham-operated groups 3 and 4 received no treatment. Seven days after the last treatment, the OA was classified macroscopically and the hyaline cartilage of the affected area was evaluated histologically according to the Mankin scale.
RESULTS: Macroscopically, OA was lower in group 1 (p < 0.01), while in group 2 (p = 0.11) it was not significant compared to the sham groups. There was no significant difference in the Mankin score in both treated groups compared to the control groups (group 1: p = 0.36; group 2: p = 0.81).
CONCLUSIONS: The results showed a certain positive macroscopic effect in mild OA with fewer macroscopic signs of OA in the treated animals, but without any histological effect on the Mankin scale. No effect was observed in later-stage OA. Based on these results, NMR cannot be recommended for the treatment of post-traumatic OA at this time.
Steinecker-Frohnwieser & W. Kullich, 2011: Positive Effects of the Therapeutic Use of Nuclear Magnetic Resonance in Treating Sports Horses Suffering from Ganglia, Saalfelden, Cluster for Rheumatology, Balneology and Rehabilitation
Injuries to the lower extremities of horses involved in equine sports can when inflamed or swollen lead to the formation of ganglia and, depending on the location of the ganglion, can thus also lead to problems in natural movement. Conventional methods of treatment using corticoid ointments or phytotherapeutics are generally long-winded and require – as does the frequently performed surgical removal – a relatively long period of convalescence. In this case study nuclear magnetic resonance was used for the first time as a means of treating a ganglion on such a horse. Nuclear magnetic resonance, which is physically based on the same principle as that used in the MRI imaging procedure and has been successfully used as a means of treating ailments of the musculoskeletal system in human medicine, now represents a new form of treatment, via which it was possible to achieve an enduring resolution of the treated ganglion using non-invasive means with 9 sessions of treatment in just 10 days. In follow-up examinations after the treatment, after 6 weeks, 4 months, 1 year and 2 years, it could further be shown that there was no evidence of the ganglion a year later and that two years after the nuclear magnetic resonance treatment there was also no recurrence of any ganglion in this area. As a consequence of this observation, nuclear magnetic resonance treatment could therefore represent an alternative and very promising method of treating ganglia with very short periods of inactivity for the horse.
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