{"id":27029,"date":"2025-03-05T13:14:31","date_gmt":"2025-03-05T12:14:31","guid":{"rendered":"https:\/\/mbst.air3.ch\/?page_id=27029"},"modified":"2025-08-11T15:30:03","modified_gmt":"2025-08-11T13:30:03","slug":"fundamental-science","status":"publish","type":"page","link":"https:\/\/mbst.com\/en\/doctor\/science\/fundamental-science\/","title":{"rendered":"fundamental-science"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"27029\" class=\"elementor elementor-27029 elementor-17477\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ec4aa0b e-con-full e-flex e-con e-parent\" data-id=\"ec4aa0b\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-5f85483 pad_section e-flex e-con-boxed e-con e-child\" data-id=\"5f85483\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d7768ff e-con-full e-flex e-con e-child\" data-id=\"d7768ff\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-13d6294 elementor-widget elementor-widget-heading\" data-id=\"13d6294\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">MBST\u00ae Science &amp; Research<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-046e8aa elementor-widget elementor-widget-heading\" data-id=\"046e8aa\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Basic Research | In-vitro-studies<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-94fa982 e-con-full e-flex e-con e-child\" data-id=\"94fa982\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9f2dc31 elementor-widget elementor-widget-image\" data-id=\"9f2dc31\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1041\" height=\"613\" src=\"https:\/\/mbst.com\/wp-content\/uploads\/2025\/05\/wissenschaft-banner.webp\" class=\"attachment-full size-full wp-image-22838\" alt=\"\" srcset=\"https:\/\/mbst.com\/wp-content\/uploads\/2025\/05\/wissenschaft-banner.webp 1041w, https:\/\/mbst.com\/wp-content\/uploads\/2025\/05\/wissenschaft-banner-300x177.webp 300w, https:\/\/mbst.com\/wp-content\/uploads\/2025\/05\/wissenschaft-banner-1024x603.webp 1024w, https:\/\/mbst.com\/wp-content\/uploads\/2025\/05\/wissenschaft-banner-768x452.webp 768w\" sizes=\"(max-width: 1041px) 100vw, 1041px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-362da14 e-con-full accordionGroup e-flex e-con e-child\" data-id=\"362da14\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-8ade954 e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"8ade954\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-ff06a08 accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"ff06a08\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7462f60 elementor-widget elementor-widget-heading\" data-id=\"7462f60\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2025<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef9534c elementor-widget elementor-widget-heading\" data-id=\"ef9534c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Cellular effects of magnetic resonance<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7db1b5c elementor-widget elementor-widget-text-editor\" data-id=\"7db1b5c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Th\u00f6ni, A. Buchter, A. Flarer, J. Lampe, C. Schlegel &amp; M. Egg., 2025:<\/strong> Understanding therapeutic nuclear magnetic resonance (tNMR): splitting of components indicates its unique efficacy, Poster presentation, BiOS, 2025, San Francisco, California, USA, in <a href=\"https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/13340.toc\">Proceedings Volume 13340, Quantum Effects and Measurement Techniques in Biology and Biophotonics II;<\/a>133400E (2025)<\/p><ul><li>DOI: <a href=\"https:\/\/doi.org\/10.1117\/12.3056086\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">10.1117\/12.3056086<\/span><\/a><\/li><\/ul><p>\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-543f618 e-con-full group-btn e-flex e-con e-child\" data-id=\"543f618\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-83851b5 border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"83851b5\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6870c97 elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"6870c97\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e5fcfa blue-btn elementor-widget elementor-widget-button\" data-id=\"3e5fcfa\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.1117\/12.3056086\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cfd6173 e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"cfd6173\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-0a806bf e-con-full accordion-summary e-flex e-con e-child\" data-id=\"0a806bf\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-7698f96 pad_section e-flex e-con-boxed e-con e-child\" data-id=\"7698f96\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ecbb7f2 elementor-widget elementor-widget-heading\" data-id=\"ecbb7f2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-096a4b2 elementor-widget elementor-widget-text-editor\" data-id=\"096a4b2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Therapeutic Nuclear Magnetic Resonance (tNMR, MBST\u00ae, Wetzlar, Germany) was derived from MRI, reducing the magnetic field intensity to 0.4mT and the radiofrequency to &lt;18kHz, to induce water proton resonance conditions. However, it was unknown whether proton resonances were essential for the manifold cellular effects observed, such as changes in the circadian clock, the hypoxic signaling pathway and in reactive oxygen species (ROS). Therefore, chip cards were designed to selectively induce either tNMR, the sweep field (0.4mT, 50Hz) or the radiofrequency (up to 18kHz). Preliminary data now indicate distinct cellular responses for each of the three modes, regarding ROS partitioning, lactate metabolism, and cellular proliferation rates. Interestingly, tNMR affected cellular processes known to require proton gradients, such as mitochondrial respiration and lactate shuttling via proton-coupled Monocarboxylate Transporters. This suggests that tNMR potentially enhances cellular proton motive forces. Conclusively, our results highlight a huge potential for all three applications, tNMR, sweep field and radiofrequency, and emphasize the unique role of tNMR.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-715b672 e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"715b672\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-88d5761 accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"88d5761\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d44538b elementor-widget elementor-widget-heading\" data-id=\"d44538b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2025<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8fd40ba elementor-widget elementor-widget-heading\" data-id=\"8fd40ba\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Weak magnetic fields and ROS in cancer treatment<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7ccfe elementor-widget elementor-widget-text-editor\" data-id=\"ad7ccfe\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Egg &amp; T. Kietzmann, 2025:<\/strong> Little strokes fell big oaks: The use of weak magnetic fields and reactive oxygen species to fight cancer, Redox Biology 79 (2025) 103483<\/p><ul><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39729909\/\" target=\"_blank\" rel=\"noopener\">DOI: <span style=\"text-decoration: underline;\">10.1016\/j.redox.2024.103483<\/span><\/a><\/li><li><span style=\"text-decoration: underline;\"><a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213-2317(24)00461-0\" target=\"_blank\" rel=\"noopener\">https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213-2317(24)00461-0<\/a><\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f917fbb e-con-full group-btn e-flex e-con e-child\" data-id=\"f917fbb\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22378ae border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"22378ae\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-63b0677 elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"63b0677\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c069ff0 blue-btn elementor-widget elementor-widget-button\" data-id=\"c069ff0\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39729909\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bf37d43 e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"bf37d43\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-d0166f5 e-con-full accordion-summary e-flex e-con e-child\" data-id=\"d0166f5\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-b32d57b pad_section e-flex e-con-boxed e-con e-child\" data-id=\"b32d57b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-046ed6c elementor-widget elementor-widget-heading\" data-id=\"046ed6c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-096c317 elementor-widget elementor-widget-text-editor\" data-id=\"096c317\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The increase in early-stage cancers, particularly gastrointestinal, breast and kidney cancers, has been linked to lifestyle changes such as consumption of processed foods and physical inactivity, which contribute to obesity and diabetes &#8211; major cancer risk factors. Conventional treatments such as chemotherapy and radiation often lead to severe long-term side effects, including secondary cancers and tissue damage, highlighting the need for new, safer and more effective therapies, especially for young patients. Weak electromagnetic fields (WEMF) offer a promising non-invasive approach to cancer treatment. While WEMF have been used therapeutically for musculoskeletal disorders for decades, their role in oncology is still emerging. WEMFs affect multiple cellular processes through mechanisms such as the radical pair mechanism (RPM), which alters reactive oxygen species (ROS) levels, mitochondrial function, and glycolysis, among others. This review explores the potential of WEMF in conjunction with reactive oxygen species as a cancer therapy, highlighting WEMFs selective targeting of cancer cells and its non-ionizing nature, which could reduce collateral damage compared to conventional treatments. In addition, synchronization of WEMF with circadian rhythms may further enhance its therapeutic efficacy, as has been demonstrated in other cancer therapies.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a06c5f5 e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"a06c5f5\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-2bfc070 accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"2bfc070\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f83f9e elementor-widget elementor-widget-heading\" data-id=\"7f83f9e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2024<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9f5817 elementor-widget elementor-widget-heading\" data-id=\"e9f5817\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Triggering clock-dependent effects in cellular <br>clocks and the central role of superoxide<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e38c96e elementor-widget elementor-widget-text-editor\" data-id=\"e38c96e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Thoeni, E. Y. Dimova, T. Kietzmann, R. J. Usselman &amp; M. Egg, 2024:<\/strong> Therapeutic nuclear magnetic resonance and intermittent hypoxia trigger time dependent on\/off effects in circadian clocks and confirm a central role of superoxide in cellular magnetic field effects, Redox Biology, 06\/2024, 72, 103152<\/p><ul><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38593630\/\" target=\"_blank\" rel=\"noopener\">DOI: <span style=\"text-decoration: underline;\">10.1016\/j.redox.2024.103152<\/span><\/a><\/li><li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2213231724001289?via%3Dihub\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">Therapeutic nuclear magnetic resonance and intermittent hypoxia trigger time dependent on\/off effects in circadian clocks and confirm a central role of superoxide in cellular magnetic field effects &#8211; ScienceDirect<\/span><\/a><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d843d5a e-con-full group-btn e-flex e-con e-child\" data-id=\"d843d5a\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cdd621e border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"cdd621e\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b7deeb elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"4b7deeb\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06769b0 blue-btn elementor-widget elementor-widget-button\" data-id=\"06769b0\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38593630\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e757495 e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"e757495\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-376c79a e-con-full accordion-summary e-flex e-con e-child\" data-id=\"376c79a\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-aa782cf pad_section e-flex e-con-boxed e-con e-child\" data-id=\"aa782cf\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-19e98f0 elementor-widget elementor-widget-heading\" data-id=\"19e98f0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5377a7c elementor-widget elementor-widget-text-editor\" data-id=\"5377a7c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Cellular magnetic field effects are assumed to base on coherent singlet-triplet interconversion of radical pairs that are sensitive to applied radiofrequency (RF) and weak magnetic fields (WEMFs), known as radical pair mechanism (RPM). As a leading model, the RPM explains how quantum effects can influence biochemical and cellular signalling. Consequently, radical pairs generate reactive oxygen species (ROS) that link the RPM to redox processes, such as the response to hypoxia and the circadian clock. Therapeutic nuclear magnetic resonance (tNMR) occupies a unique position in the RPM paradigm because of the used frequencies, which are far below the range of 0.1\u2013100 MHz postulated for the RPM to occur. Nonetheless, tNMR was shown to induce RPM like effects, such as increased extracellular H2O2 levels and altered cellular bioenergetics. In this study we compared the impact of tNMR and intermittent hypoxia on the circadian clock, as well as the role of superoxide in tNMR induced ROS partitioning. We show that both, tNMR and intermittent hypoxia, exert on\/off effects on cellular clocks that are dependent on the time of application (day versus night). In addition, our data provide further evidence that superoxide plays a central role in magnetic signal transduction. tNMR used in combination with scavengers, such as Vitamin C, led to strong ROS product redistributions. This discovery might represent the first indication of radical triads in biological systems.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0343149 e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"0343149\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-d937af1 accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"d937af1\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-739aad5 elementor-widget elementor-widget-heading\" data-id=\"739aad5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2024<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4af88fc elementor-widget elementor-widget-heading\" data-id=\"4af88fc\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Influence on Schwann cells and <br>promotion of neurite growth<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d7100e elementor-widget elementor-widget-text-editor\" data-id=\"4d7100e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Rad, L. Weigl, B. Steinecker-Frohnwieser, S. Stadlmayr, F. Millesi, M. Haertinger, A. Borger, P. Supper, L. Semmler, S. Wolf, A. Naghilou, T. Weiss, H. G. Kress &amp; C. Radtke, 2024:<\/strong> Nuclear Magnetic Resonance Treatment Induces \u00dfNGF Release from Schwann Cells and Enhances the Neurite Growth of Dorsal Root Ganglion Neurons In Vitro, Cells, 13, 1544.<\/p><ul><li>DOI: <a href=\"https:\/\/doi.org\/10.3390\/cells13181544\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">10.3390\/cells13181544<\/span><\/a><\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39329728\/\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">Nuclear Magnetic Resonance Treatment Induces \u00dfNGF Release from Schwann Cells and Enhances the Neurite Growth of Dorsal Root Ganglion Neurons In Vitro &#8211; PubMed<\/span><\/a><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9d98753 e-con-full group-btn e-flex e-con e-child\" data-id=\"9d98753\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-301537c border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"301537c\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e636ee9 elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"e636ee9\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a846e0f blue-btn elementor-widget elementor-widget-button\" data-id=\"a846e0f\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.3390\/cells13181544\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-df73432 e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"df73432\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-6bbf143 e-con-full accordion-summary e-flex e-con e-child\" data-id=\"6bbf143\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-b34cd00 pad_section e-flex e-con-boxed e-con e-child\" data-id=\"b34cd00\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1ae7fb8 elementor-widget elementor-widget-heading\" data-id=\"1ae7fb8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fff798a elementor-widget elementor-widget-text-editor\" data-id=\"fff798a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Peripheral nerve regeneration depends on close interaction between neurons and Schwann cells (SCs). After nerve injury, SCs produce growth factors and cytokines that are crucial for axon re-growth. Previous studies revealed the supernatant of SCs exposed to nuclear magnetic resonance therapy (NMRT) treatment to increase survival and neurite formation of rat dorsal root ganglion (DRG) neurons in vitro. The aim of this study was to identify factors involved in transferring the observed NMRT-induced effects to SCs and consequently to DRG neurons. Conditioned media of NMRT-treated (CM NMRT) and untreated SCs (CM CTRL) were tested by beta-nerve growth factor (\u00dfNGF) ELISA and multiplex cytokine panels to profile secreted factors. The expression of nociceptive transient receptor potential vanilloid 1 (TRPV1) channels was assessed and the intracellular calcium response in DRG neurons to high-potassium solution, capsaicin or adenosine triphosphate was measured mimicking noxious stimuli. NMRT induced the secretion of \u00dfNGF and pro-regenerative-signaling factors. Blocking antibody experiments confirmed \u00dfNGF as the main factor responsible for neurotrophic\/neuritogenic effects of CM NMRT. The TRPV1 expression or sensitivity to specific stimuli was not altered, whereas the viability of cultured DRG neurons was increased. Positive effects of CM NMRT supernatant on DRG neurons are primarily mediated by increased \u00dfNGF levels.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4537714 e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"4537714\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-c9f9bae accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"c9f9bae\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e9fee8c elementor-widget elementor-widget-heading\" data-id=\"e9fee8c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2022<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-beb0b13 elementor-widget elementor-widget-heading\" data-id=\"beb0b13\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Quantum effects of magnetic <br>resonance reduce glycolysis <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-80f1eda elementor-widget elementor-widget-text-editor\" data-id=\"80f1eda\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Th\u00f6ni, D. Mauracher, A. Ramalingam, B. Fiechtner, A. M. Sandbichler &amp; M. Egg, 2022:<\/strong> Quantum based effects of therapeutic nuclear magnetic resonance persistently reduce glycolysis, iScience, 12\/2022<\/p><ul><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36444297\/\" target=\"_blank\" rel=\"noopener\">DOI: <span style=\"text-decoration: underline;\">10.1016\/j.isci.2022.105536<\/span><\/a><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-007e367 e-con-full group-btn e-flex e-con e-child\" data-id=\"007e367\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a858925 border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"a858925\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-057e9b5 elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"057e9b5\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc56082 blue-btn elementor-widget elementor-widget-button\" data-id=\"bc56082\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36444297\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c41482f e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"c41482f\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-6a224e2 e-con-full accordion-summary e-flex e-con e-child\" data-id=\"6a224e2\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-a6e8d01 pad_section e-flex e-con-boxed e-con e-child\" data-id=\"a6e8d01\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5702cf3 elementor-widget elementor-widget-heading\" data-id=\"5702cf3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a7c731 elementor-widget elementor-widget-text-editor\" data-id=\"7a7c731\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Electromagnetic fields are known to induce the clock protein cryptochrome to modulate intracellular reactive oxygen species (ROS) via the quantum based radical pair mechanism (RPM) in mammalian cells. Recently, therapeutic Nuclear Magnetic Resonance (tNMR) was shown to alter protein levels of the circadian clock associated Hypoxia Inducible Factor-1a (HIF-1a) in a nonlinear dose response relationship. Using synchronized NIH3T3 cells, we show that tNMR under normoxia and hypoxia persistently modifies cellular metabolism. After normoxic tNMR treatment, glycolysis is reduced, as are lactate production, extracellular acidification rate, the ratio of ADP\/ATP and cytosolic ROS, whereas mitochondrial and extracellular ROS, as well as cellular proliferation are increased. Remarkably, these effects are even more pronounced after hypoxic tNMR treatment, driving cellular metabolism to a reduced glycolysis while mitochondrial respiration is kept constant even during reoxygenation. Hence, we propose tNMR as a potential therapeutic tool in ischemia driven diseases like inflammation, infarct, stroke and cancer.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bd98672 e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"bd98672\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-8f09589 accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"8f09589\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d39ed9c elementor-widget elementor-widget-heading\" data-id=\"d39ed9c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2022<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f9e32f4 elementor-widget elementor-widget-heading\" data-id=\"f9e32f4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Magnetic resonance accelerates <br>regeneration of ganglion neurons <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aab05b0 elementor-widget elementor-widget-text-editor\" data-id=\"aab05b0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Mann, B. Steinecker-Frohnwieser, A. Naghilou, F. Millesi, P. Supper, L. Semmler, S. Wolf, L. Marinova, L. Weigl, T. Weiss &amp; C. Radtke, 2022:<\/strong> Nuclear Magnetic Resonance Treatment Accelerates the Regeneration of Dorsal Root Ganglion Neurons in vitro, Frontiers in Cellular Neuroscience, 03\/2022, 16, 859545<\/p><ul><li>DOI: <a href=\"https:\/\/doi.org\/10.3389\/fncel.2022.859545\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">10.3389\/fncel.2022.859545<\/span><\/a><\/li><li><a href=\"https:\/\/www.frontiersin.org\/journals\/cellular-neuroscience\/articles\/10.3389\/fncel.2022.859545\/full\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">Nuclear Magnetic Resonance Treatment Accelerates the Regeneration of Dorsal Root Ganglion Neurons in vitro &#8211; PubMed<\/span><\/a><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7e9edc5 e-con-full group-btn e-flex e-con e-child\" data-id=\"7e9edc5\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6fd5db7 border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"6fd5db7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f7a7e7c elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"f7a7e7c\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-59633d8 blue-btn elementor-widget elementor-widget-button\" data-id=\"59633d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.3389\/fncel.2022.859545\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73248de e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"73248de\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-8101c44 e-con-full accordion-summary e-flex e-con e-child\" data-id=\"8101c44\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-c899827 pad_section e-flex e-con-boxed e-con e-child\" data-id=\"c899827\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-54d6743 elementor-widget elementor-widget-heading\" data-id=\"54d6743\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-491acda elementor-widget elementor-widget-text-editor\" data-id=\"491acda\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Functional recovery from peripheral nerve injuries depends on a multitude of factors. Schwann cells (SCs) are key players in the regenerative process as they develop repair-specific functions to promote axon regrowth. However, chronically denervated SCs lose their repair phenotype, which is considered as a main reason for regeneration failure. Previous studies reported a modulatory effect of low nuclear magnetic resonance therapy (NMRT) on cell proliferation and gene expression. To provide first insight into a possible effect of NMRT on cells involved in peripheral nerve regeneration, this study investigated whether NMRT is able to influence the cellular behavior of primary SC and dorsal root ganglion (DRG) neuron cultures in vitro. The effect of NMRT on rat SCs was evaluated by comparing the morphology, purity, proliferation rate, and expression levels of (repair) SC associated genes between NMRT treated and untreated SC cultures. In addition, the influence of (1) NMRT and (2) medium obtained from NMRT treated SC cultures on rat DRG neuron regeneration was examined by analyzing neurite outgrowth and the neuronal differentiation status. Our results showed that NMRT stimulated the proliferation of SCs without changing their morphology, purity, or expression of (repair) SC associated markers. Furthermore, NMRT promoted DRG neuron regeneration shown by an increased cell survival, enhanced neurite network formation, and progressed neuronal differentiation status. Furthermore, the medium of NMRT treated SC cultures was sufficient to support DRG neuron survival and neurite outgrowth. These findings demonstrate a beneficial impact of NMRT on DRG neuron survival and neurite formation, which is primarily mediated via SC stimulation. Our data suggest that NMRT could be suitable as a non-invasive auxiliary treatment option for peripheral nerve injuries and encourage future studies that investigate the effect of NMRT in a physiological context.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b396458 e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"b396458\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-cf931e3 accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"cf931e3\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8d857be elementor-widget elementor-widget-heading\" data-id=\"8d857be\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2021<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8bbbb7 elementor-widget elementor-widget-heading\" data-id=\"f8bbbb7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Influencing central clock mechanisms and hypoxia <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce52617 elementor-widget elementor-widget-text-editor\" data-id=\"ce52617\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Th\u00f6ni, R. Oliva, D. Mauracher &amp; M. Egg, 2021:<\/strong> Therapeutic Nuclear Magnetic Resonance affects the core clock mechanism and associated Hypoxia-inducible factor-1, Chronobiology international,\u00a038(8), 1120\u20131134<\/p><ul><li>DOI: <span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33847185\/\" target=\"_blank\" rel=\"noopener\">10.1080\/07420528.2021.1910288<\/a><\/span><\/li><li><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07420528.2021.1910288\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">Full article: Therapeutic Nuclear Magnetic Resonance affects the core clock mechanism and associated Hypoxia-inducible factor-1<\/span><\/a><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7b42f89 e-con-full group-btn e-flex e-con e-child\" data-id=\"7b42f89\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a9caa03 border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"a9caa03\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e8dd4c7 elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"e8dd4c7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c8c84b blue-btn elementor-widget elementor-widget-button\" data-id=\"1c8c84b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33847185\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3cfb6f9 e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"3cfb6f9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-1958447 e-con-full accordion-summary e-flex e-con e-child\" data-id=\"1958447\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-6e095e9 pad_section e-flex e-con-boxed e-con e-child\" data-id=\"6e095e9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-91b487c elementor-widget elementor-widget-heading\" data-id=\"91b487c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b6cdf6 elementor-widget elementor-widget-text-editor\" data-id=\"4b6cdf6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The influence of low intensity electromagnetic fields on circadian clocks of cells and tissues has gained increasing scientific interest, either as a therapeutic tool or as a potential environmental hazard. Nuclear Magnetic Resonance (NMR) refers to the property of certain atomic nuclei to absorb the energy of radio waves under a corresponding magnetic field. NMR forms the basis for Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy and, in a low-intensity form, for NMR therapy (tNMR). Since the circadian clock is bi-directionally intertwined with hypoxic signaling in vertebrates and mammals, we hypothesized that low intensity electromagnetic fields, such as tNMR, might not only affect circadian clocks but also Hypoxia-Inducible Factor-1\u03b1 (HIF-1\u03b1). As master regulator of the hypoxic signaling pathway, HIF-1\u03b1 is known to dampen the circadian amplitude under reduced oxygen availability, while the hypoxic response of cells and organisms, itself, is tightly clock controlled. In a first experiment, we investigated if tNMR is able to act as Zeitgeber for the core clock mechanism of unsynchronized zebrafish and mouse fibroblast cells, using direct light irradiation and treatment with the glucocorticoid Dexamethasone as references. tNMR significantly affected the cell autonomous clocks of unsynchronized mouse fibroblast cells NIH3-T3, but did not act as a Zeitgeber. Similar to light irradiation and in contrast to treatment with Dexamethasone, tNMR did not synchronize expression profiles of murine clock genes. However, irradiation with tNMR as well as light significantly altered mRNA and protein expression levels of Cryptochrome1, Cryptochrome2 and Clock1 for more than 24 h. Changes in mRNA and protein after different treatment durations, namely 6 and 12 h, appeared to be nonlinear. A nonlinear dose-response relationship is known as hallmark of electromagnetic field induced effects on biological systems. The most prominent alterations were detected in murine HIF-1\u03b1 protein, again in a nonlinear dose\u2013response. In contrast to murine cells, zebrafish fibroblasts did not respond to tNMR at all. Light, a potent Zeitgeber for the peripheral clocks of fish, led to the expected synchronized clock gene oscillations of high amplitude, as did Dexamethasone. Hence, we conclude, mammalian peripheral clocks are more susceptible to tNMR than the direct light entrainable fish fibroblasts. Although light and tNMR did not act as Zeitgebers for the circadian clocks of unsynchronized murine cells, the significant observed effects might indicate downstream cell-physiological ramifications, which are worth future investigation. However, beside the effects tNMR exerts on the core clock mechanism of mammalian cells, the technology might be the first non-pharmacological approach to modify HIF-1\u03b1 protein in cells and tissues. HIF-1\u03b1 and the associated circadian clock play key roles in diseases with underlying ischemic background, such as infarct, stroke, and cancer and, also infectious diseases, such as Covid<strong>&#8211;<\/strong>19. Hence, low intensity magnetic fields such as tNMR might be of significant medical interest.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ee83493 e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"ee83493\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-34cf51c accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"34cf51c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-977c369 elementor-widget elementor-widget-heading\" data-id=\"977c369\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2021<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4bb82fd elementor-widget elementor-widget-heading\" data-id=\"4bb82fd\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Magnetic resonance reduces inflammation in cells <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f380e65 elementor-widget elementor-widget-text-editor\" data-id=\"f380e65\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Steinecker-Frohnwieser, B. Lohberger, N. Eck, A. Mann, C. Kratschmann, A. Leithner, W. Kullich &amp; L. Weigl, 2021:<\/strong> Nuclear Magnetic Resonance Therapy Modulates the miRNA Profile in Human Primary OA Chondrocytes and Antagonizes Inflammation in Tc28\/2a Cells, International Journal of Molecular Sciences, 05\/2021, 22(11), 5959<\/p><ul><li>DOI: <a href=\"https:\/\/doi.org\/10.3390\/ijms22115959\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">10.3390\/ijms22115959<\/span><\/a><\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34073090\/\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">Nuclear Magnetic Resonance Therapy Modulates the miRNA Profile in Human Primary OA Chondrocytes and Antagonizes Inflammation in Tc28\/2a Cells &#8211; PubMed<\/span><\/a><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c2072af e-con-full group-btn e-flex e-con e-child\" data-id=\"c2072af\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9e89c95 border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"9e89c95\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5623241 elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"5623241\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-11709bb blue-btn elementor-widget elementor-widget-button\" data-id=\"11709bb\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.3390\/ijms22115959\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-258d76c e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"258d76c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-d134e1c e-con-full accordion-summary e-flex e-con e-child\" data-id=\"d134e1c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-8ba514f pad_section e-flex e-con-boxed e-con e-child\" data-id=\"8ba514f\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6624c27 elementor-widget elementor-widget-heading\" data-id=\"6624c27\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb7dcc2 elementor-widget elementor-widget-text-editor\" data-id=\"fb7dcc2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Nuclear magnetic resonance therapy (NMRT) is discussed as a participant in repair processes regarding cartilage and as an influence in pain signaling. To substantiate the application of NMRT, the underlying mechanisms at the cellular level were studied. In this study microRNA (miR) was extracted from human primary healthy and osteoarthritis (OA) chondrocytes after NMR treatment and was sequenced by the Ion PI Hi-Q\u2122 Sequencing 200 system. In addition, T\/C-28a2 chondrocytes grown under hypoxic conditions were studied for IL-1 induced changes in expression on RNA and protein level. HDAC activity an NAD(+)\/NADH was measured by luminescence detection. In OA chondrocytes miR-106a, miR-27a, miR-34b, miR-365a and miR-424 were downregulated. This downregulation was reversed by NMRT. miR-365a-5p is known to directly target HDAC and NF-kB, and a decrease in HDAC activity by NMRT was detected. NAD+\/NADH was reduced by NMR treatment in OA chondrocytes. Under hypoxic conditions NMRT changed the expression profile of HIF1, HIF2, IGF2, MMP3, MMP13, and RUNX1. We conclude that NMRT changes the miR profile and modulates the HDAC and the NAD(+)\/NADH signaling in human chondrocytes. These findings underline once more that NMRT counteracts IL-1 induced changes by reducing catabolic effects, thereby decreasing inflammatory mechanisms under OA by changing NF-kB signaling.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-75461e8 e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"75461e8\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-b57a2a1 accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"b57a2a1\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5dac9b3 elementor-widget elementor-widget-heading\" data-id=\"5dac9b3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2019<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-949f18f elementor-widget elementor-widget-heading\" data-id=\"949f18f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Comparison of the impact of light, magnetic <br>resonance and dexamethasone on cell clocks <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0bda098 elementor-widget elementor-widget-text-editor\" data-id=\"0bda098\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Th\u00f6ni, 2019:<\/strong> Impact of light radiation, nuclear magnetic resonance (NMR) and dexamethasone treatment on the transcriptional clock of the mouse fibroblast cell line NIH3T3, Master\u2019s thesis, University of Innsbruck, Department of Zoology<\/p><ul><li><span style=\"text-decoration: underline;\"><a href=\"https:\/\/mbst.com\/en\/doctor\/cloud\/\">Read the full text in our MBST-Cloud<\/a><\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-63ca5bf e-con-full group-btn e-flex e-con e-child\" data-id=\"63ca5bf\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8f505dc border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"8f505dc\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71c6533 elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"71c6533\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1208cbd blue-btn elementor-widget elementor-widget-button\" data-id=\"1208cbd\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/en\/doctor\/cloud\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d8c7a97 e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"d8c7a97\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-774a777 e-con-full accordion-summary e-flex e-con e-child\" data-id=\"774a777\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-8b03824 pad_section e-flex e-con-boxed e-con e-child\" data-id=\"8b03824\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4de28d6 elementor-widget elementor-widget-heading\" data-id=\"4de28d6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e0ae624 elementor-widget elementor-widget-text-editor\" data-id=\"e0ae624\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Nuclear magnetic resonance (NMR) is a physical phenomenon which is used for imaging (magnetic resonance imaging, MRI) and, at lower intensity, as a therapeutic tool (nuclear magnetic resonance therapy, tNMR) in regenerative medicine and for musculoskeletal disorders. However, virtually nothing is known about the biological effects of NMR. Only recently, the circadian clock of zebrafish cells and larvae was shown to be affected by the tNMR under constant darkness. In order to be able to translate these findings to humans, we now set out to investigate the impact of tNMR on a mammalian cell line, the mouse fibroblasts NIH3T3. For this purpose, we designed primers for quantitative Real time qPCR (qRT-PCR), in order to be able to quantify mRNA levels of major murine clock genes. Primer design was accomplished via the conserved regions of the core clock genes <em>Cry1, Cry2, Clock1, Per1, <\/em>and <em>Per2, <\/em>which were determined by comparing the respective mRNA sequences of zebrafish, mouse and human. We then cultured mouse (NIH3T3) and zebrafish (Z3) fibroblasts and exposed them either directly to light, tNMR or dexamethasone. The comparison between the different treatments was performed in order to be able to characterize the effects of tNMR also qualitatively. Our results demonstrate that the tNMR did not synchronize the transcriptional clock of mouse fibroblasts as dexamethasone did. However, tNMR significantly reduced the mRNA expression of the murine C<em>ry1<\/em>, <em>Cry2<\/em>, <em>Clock1, <\/em>and <em>Per2 <\/em>genes under constant dark conditions. The tNMR induced effects in mouse cells thereby resembled those of direct light exposure, which also led to reduced mRNA expression levels of specific clock genes. The transcriptional clock of zebrafish cells, in turn, was affected by dexamethasone and synchronized by light, as known from literature, but did not respond to the treatment with tNMR. Interestingly, the affected murine clock genes play a crucial role in bone formation and in the anti-inflammatory immune response. Hence, this study supports the potential of tNMR as therapeutic tool for chronic diseases linked to the circadian clock, although further research at the protein level has to be done.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c75f28d e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"c75f28d\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-6284edd accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"6284edd\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-86b62a4 elementor-widget elementor-widget-heading\" data-id=\"86b62a4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2018<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5252f76 elementor-widget elementor-widget-heading\" data-id=\"5252f76\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Influence on intracellular calcium and inflammatory processes <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-261e85e elementor-widget elementor-widget-text-editor\" data-id=\"261e85e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Steinecker-Frohnwieser, W. Kullich, A. Mann, H. G. Kress &amp; L. Weigl, 2018:<\/strong> The therapeutic nuclear magnetic resonance changes the balance in intracellular calcium and reduces the interleukin-1\u03b2 induced increase of NF-\u03baB activity in chondrocytes, Clinical and Experimental Rheumatology 2018, 36, 294\u2013301<\/p><ul><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29185963\/\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">The therapeutic nuclear magnetic resonance changes the balance in intracellular calcium and reduces the interleukin-1\u03b2 induced increase of NF-\u03baB activity in chondrocytes &#8211; PubMed<\/span><\/a><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9c1801d e-con-full group-btn e-flex e-con e-child\" data-id=\"9c1801d\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e6d726b border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"e6d726b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-83ee05f elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"83ee05f\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05710cc blue-btn elementor-widget elementor-widget-button\" data-id=\"05710cc\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29185963\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c83a2c2 e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"c83a2c2\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-54dbdbc e-con-full accordion-summary e-flex e-con e-child\" data-id=\"54dbdbc\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-31b4395 pad_section e-flex e-con-boxed e-con e-child\" data-id=\"31b4395\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-989129f elementor-widget elementor-widget-heading\" data-id=\"989129f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-01ea1d5 elementor-widget elementor-widget-text-editor\" data-id=\"01ea1d5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Objective: Osteoarthritis as the main chronic joint disease is characterised by the destruction of articular cartilage. Developing new, more effective and in particular non-invasive methods to achieve pain reduction of OA patients are of exceptional interest. Clinical observations demonstrated positive effects of therapeutically applied low nuclear magnetic resonance (NMRT) for the treatment of painful disorders of the musculoskeletal system. In this study the cellular mechanism of action of NMRT was examined on chondrocytes.<\/p><p>Methods: Cal-78 human chondrosarcoma cells were kept under inflammatory conditions by application of IL-1\u03b2. NMRT treated cells were tested for changes in histamine induced Ca<sup>2+<\/sup> release by fura-2 calcium imaging. The effects of IL-1\u03b2 and of NMRT treatment were further tested by determining intracellular ATP concentrations and the activity of MAP-kinases and NF-\u03baB.<\/p><p>Results: NMRT influenced the intracellular calcium signalling by elevating the basal [Ca<sup>2+<\/sup>]. The peak calcium concentration evoked by 10 \u03bcM histamine was increased by IL-1\u03b2 and this increase was reversed under NMRT treatment. Screening of different kinase-activities revealed an apparent increase in activity of MAPK\/ERK and MAPK\/JNK in NMRT stimulated cells, p38 was downregulated. The IL-1\u03b2-induced decline in intracellular ATP and the elevated NF-\u03baB activity was reversed under NMRT stimulation.<\/p><p>Conclusion: Under inflammatory conditions, NMRT influenced cellular functions by modulating cellular calcium influx and\/or calcium release. Further, NMRT induced changes in MAPK activities such as down-regulation of NF-\u03baB and increasing intracellular ATP might help to stabilise chondrocytes and delay cartilage damage due to OA.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-22e1531 e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"22e1531\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-11cac19 accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"11cac19\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-19728a5 elementor-widget elementor-widget-heading\" data-id=\"19728a5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2018<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-83664b1 elementor-widget elementor-widget-heading\" data-id=\"83664b1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Effects of magnetic resonance on cell clocks<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca859aa elementor-widget elementor-widget-text-editor\" data-id=\"ca859aa\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Oliva, B. Jansen, F. Benscheidt, A. M. Sandbichler &amp; M. Egg, 2018:<\/strong> Nuclear magnetic resonance affects the circadian clock and hypoxia-inducible factor isoforms in zebrafish, Biological Rhythm, Research, 2018, 5(5), 739\u2013757<\/p><ul><li>DOI: <a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/09291016.2018.1498194\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">10.1080\/09291016.2018.1498194<\/span><\/a><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c3fd891 e-con-full group-btn e-flex e-con e-child\" data-id=\"c3fd891\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6d2ec2c border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"6d2ec2c\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d7ba46f elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"d7ba46f\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e020f4 blue-btn elementor-widget elementor-widget-button\" data-id=\"1e020f4\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/09291016.2018.1498194\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a81078c e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"a81078c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-948d8a4 e-con-full accordion-summary e-flex e-con e-child\" data-id=\"948d8a4\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-fef9d58 pad_section e-flex e-con-boxed e-con e-child\" data-id=\"fef9d58\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1d12bee elementor-widget elementor-widget-heading\" data-id=\"1d12bee\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f907463 elementor-widget elementor-widget-text-editor\" data-id=\"f907463\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Nuclear magnetic resonance (NMR) is used for magnetic resonance imaging and, at a lower intensity, as therapy for the treatment of musculoskeletal disorders. Due to the involvement of the circadian clock protein CRYPTOCHROME in the magnetic orientation of animals, it was repeatedly assumed that magnetic fields might affect the circadian rhythm of cells and organisms. Since circadian time keeping and hypoxic signaling are mutually intertwined, we investigated the effects of NMR on both cellular pathways in zebrafish fibroblast cells and larvae. In cells, basal mRNA expression of cryptochrome1aa was increased and oscillations of cryptochrome1aa and period1b were shifted in phase, while those of clock1a and period2 remained unaffected. Similarly, circadian oscillations of cryptochrome1aa and period1b were restored in zebrafish larvae, while those of clock1a and period2 remained unaltered. NMR also restored the circadian expression of the hypoxia-inducible factor (Hif) isoforms Hif-1\u03b1 and Hif-3\u03b1 at the mRNA and protein level, but had no effect on the expression of Hif-2\u03b1. Thus, NMR-mediated effects might differ substantially from the light-induced reset of the circadian clock in the same species and therefore represent an additional operation mode of the cellular clock, enabling distinct processing of photic and magnetic information.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-536d89d e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"536d89d\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4a681ab accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"4a681ab\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-425b68b elementor-widget elementor-widget-heading\" data-id=\"425b68b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2015<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5099e4b elementor-widget elementor-widget-heading\" data-id=\"5099e4b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Effects of NMRT on liver regeneration<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4e0800b elementor-widget elementor-widget-text-editor\" data-id=\"4e0800b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Budny, 2015:<\/strong> Effects of magnetic resonance therapy on the dynamics of liver regeneration, An experimental animal study, Inaugural dissertation, Medical Faculty of the Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, from the University Hospital M\u00fcnster, Clinic for General and Visceral Surgery<\/p><ul><li><span style=\"text-decoration: underline;\"><a href=\"https:\/\/mbst.com\/en\/doctor\/cloud\/\">Read the full text in our MBST-Cloud<\/a><\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-70aca8d e-con-full group-btn e-flex e-con e-child\" data-id=\"70aca8d\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7720ee9 border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"7720ee9\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ac45675 elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"ac45675\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-925ea49 blue-btn elementor-widget elementor-widget-button\" data-id=\"925ea49\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/en\/doctor\/cloud\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-94d3915 e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"94d3915\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-73c420e e-con-full accordion-summary e-flex e-con e-child\" data-id=\"73c420e\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-0409d7c pad_section e-flex e-con-boxed e-con e-child\" data-id=\"0409d7c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d733474 elementor-widget elementor-widget-heading\" data-id=\"d733474\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ecfe047 elementor-widget elementor-widget-text-editor\" data-id=\"ecfe047\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Nuclear magnetic resonance therapy, which can be repeated at will, has proven to be an innovative therapy for degenerative diseases such as osteoarthritis or osteoporosis. To investigate the effect of magnetic resonance therapy on liver regeneration after 70% liver resection and on untreated liver tissue, 108 male Lewis rats were randomized into six experimental groups. These included three control groups, in which only the abdomen was opened, and three resection groups &#8211; with a group size of n = 18 animals. In each group, either sham treatment or simultaneous application of magnetic resonance with one of two different programs (dose I or II) was performed on the first three postoperative days. Liver biopsies were taken on days 4, 7 and 14 after intravenous administration of 100 mg\/ml bromodeoxyuridine (BrdU) per kg body weight. Weight and various serum parameters (AST, ALT, alkaline phosphatase) were examined as markers for possible liver damage. The progress of liver regeneration was assessed with mitoses, mitoses in the S phase, signs of inflammation, cell necrosis, connective tissue, glycogen and angiogenesis. Overall, no detrimental effect of the non-invasive procedure on healthy tissue was detected. Both programs had different effects on healthy and regenerating liver tissue. Regenerating tissue showed significantly faster proliferation under dose I than under dose II.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-118233c e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"118233c\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-3cf66c6 accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"3cf66c6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9088d77 elementor-widget elementor-widget-heading\" data-id=\"9088d77\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2014<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b044e03 elementor-widget elementor-widget-heading\" data-id=\"b044e03\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Influence of NMRT on chondrocytes<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3c7cea3 elementor-widget elementor-widget-text-editor\" data-id=\"3c7cea3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Steinecker-Frohnwieser, L. Weigl, G. Weberhofer, W. Kullich &amp; H. G. Kress, 2014:<\/strong> The Influence of Nuclear Magnetic Resonance Therapy (NMRT) and Interleukin IL1-b Stimulation on Cal 78 Chondrosarcoma Cells and C28\/I2 Chondrocytes, Journal of Orthopedics and Rheumatology, 2014, 1(3), 1\u20139<\/p><ul><li><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.avensonline.org\/wp-content\/uploads\/JOR-2334-2846-01-0010.pdf\" target=\"_blank\" rel=\"noopener\">The Influence of Nuclear Magnetic Resonance Therapy (NMRT) and Interleukin IL1-b Stimulation on Cal 78 Chondrosarcoma Cells and C28\/I2 Chondrocytes<\/a><\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-662255d e-con-full group-btn e-flex e-con e-child\" data-id=\"662255d\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6326ba7 border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"6326ba7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-04c2440 elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"04c2440\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-68eae41 blue-btn elementor-widget elementor-widget-button\" data-id=\"68eae41\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.avensonline.org\/wp-content\/uploads\/JOR-2334-2846-01-0010.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-09cf8ec e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"09cf8ec\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-ac874b9 e-con-full accordion-summary e-flex e-con e-child\" data-id=\"ac874b9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-8c3a005 pad_section e-flex e-con-boxed e-con e-child\" data-id=\"8c3a005\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-567e30e elementor-widget elementor-widget-heading\" data-id=\"567e30e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60e3857 elementor-widget elementor-widget-text-editor\" data-id=\"60e3857\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Introduction: For the last decade the Nuclear Magnetic Resonance (NMR) therapy has turned out a success in pain treatment of patients who suffer from osteoarthritis (OA) of knees or hands, low back pain and osteoporosis, respectively. While clinical outcome could be proved, less is known \u00a0about the underlying mechanism by which NMRT modulates cellular processes leading to observed pain reduction. This study implements the analysis of potential signal transduction pathways involved in NMRT signal transfer in Cal-78 chondrosarcoma cells and NMRT influencing cell growth and viability of interleukin IL-1\u03b2 stimulated Cal-78 cells and C28\/I2 chondrocytes. Changes in expression of inflammatory proteins like metalloproteinases MMP1, MMP3, MMP8, MMP9, MMP10 and MMP13, as well as interleukins IL6 and IL8 were evaluated.<\/p><p>Methods: Basic pathway analysis was performed by the gene array technology ensued by the reporter-gene technique (Cignal\u2122 Reporter Assay). Cell proliferation was tested by calcein- and eFlour 670 staining; the S-phase of the cells was determined by use of the BrdU assay. Changes in expression of the inflammatory proteins were evaluated by performing quantitative RT-PCR, enzyme immuno assays and luminex measurements.<\/p><p>Results: The interpretation of the gene array combined with the results of the reporter gene assay roughly reveals indices of NMRT influencing the transforming growth factor (TGF)- \u03b2 and Mitogen Activated Protein (MAP) kinase pathway. The cell growth and viability of both cell lines was not changed by NMRT although their inhibition caused by IL-1\u03b2 was more pronounced in the absence of NMRT stimulation. Even though IL-1\u03b2 provably stimulated the increase of the expression of MMPs and ILs, these effects seemed to be divergently regulated within the two cell lines. Interestingly at the level of RNA MMP13 and IL-8 are statistically down regulated by NMRT only in C28\/ I2 cells.<\/p><p>Conclusion: Our findings concerning effects of IL-1\u03b2 being less significant under NMRT than under control conditions, plus the reduced MMP-13 expression substantiate the postulated anti-inflammatory effect of NMRT relevant for pain relief. Clarification of how NMRT signaling is processed by targeted cells will broaden perspectives for clinical adaptations of NMRT by more precise and efficient application of this alternative therapeutically action.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-155042c e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"155042c\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-766ecce accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"766ecce\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-24a0be8 elementor-widget elementor-widget-heading\" data-id=\"24a0be8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2014<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dfe0bed elementor-widget elementor-widget-heading\" data-id=\"dfe0bed\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Effects of therapeutic magnetic <br>resonance on the circadian clock <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c5f7058 elementor-widget elementor-widget-text-editor\" data-id=\"c5f7058\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Oliva, 2014:<\/strong> Effects of Therapeutic-NMR (MBST\u00ae-Nuclear Magnetic Resonance) on the Circadian Clock and the Hypoxic Signaling Pathway in Zebrafish Cells, Master thesis for the acquisition of the academic degree Master of Science (MSc) at the faculty of biology Leopold Franzens University of Innsbruck, Department of Ecophysiology<\/p><ul><li><span style=\"text-decoration: underline;\"><a href=\"https:\/\/mbst.com\/en\/doctor\/cloud\/\">Read the full text in our MBST-Cloud<\/a><\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e2eb5df e-con-full group-btn e-flex e-con e-child\" data-id=\"e2eb5df\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f045bda border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"f045bda\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28f9ce7 elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"28f9ce7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aed0d4e blue-btn elementor-widget elementor-widget-button\" data-id=\"aed0d4e\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/en\/doctor\/cloud\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e78e86c e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"e78e86c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-537ddc3 e-con-full accordion-summary e-flex e-con e-child\" data-id=\"537ddc3\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-84f2286 pad_section e-flex e-con-boxed e-con e-child\" data-id=\"84f2286\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e5b0746 elementor-widget elementor-widget-heading\" data-id=\"e5b0746\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7ba2c63 elementor-widget elementor-widget-text-editor\" data-id=\"7ba2c63\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Because of the lack of studies proving the effectivity of NMR on cell signaling pathways the aim of the following study was to investigate the effect of NMR (MBST\u00ae-ClosedSystem300) treatment on the circadian clock and the hypoxic signaling pathway at the molecular level.<\/p><p>For this purpose, a pilot experiment was performed to investigate the impact of treatment and sampling time on the resulting NMR (MBST\u00ae-ClosedSystem300) effect. The results of this first experiment confirmed our assumption that the daytime of the NMR (MBST\u00ae-ClosedSystem300) treatment might be crucial.<\/p><p>In summary, the NMR (MBST\u00ae-ClosedSystem300) treatment used in the present study caused significant alterations in the circadian oscillations of specific genes, indicating that the NMR (MBST\u00ae-ClosedSystem300) treatment might significantly affect two of the most important cell signaling circuitries for the maintenance of healthy chondrocytes, the circadian clock and the hypoxic signaling pathway.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cea1652 e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"cea1652\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-b5cfeeb accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"b5cfeeb\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5542f85 elementor-widget elementor-widget-heading\" data-id=\"5542f85\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2007<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f991903 elementor-widget elementor-widget-heading\" data-id=\"f991903\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Influence on skin fibroblasts <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec597a8 elementor-widget elementor-widget-text-editor\" data-id=\"ec597a8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Digel, E. Kurulgan, P. Linder, P. Kayser, D. Porst, G. J. Braem, K. Zerlin, G. M. Artmann &amp; Temiz Artmann, 2007:<\/strong> Decrease in extracellular collagen crosslinking after NMR magnetic field application in skin fibroblasts, Medical and Biological Engineering and Computing, 45, 91\u201397<\/p><ul><li>DOI: <a href=\"https:\/\/doi.org\/10.1007\/s11517-006-0144-z\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">10.1007\/s11517-006-0144-z<\/span><\/a><\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17203317\/\" target=\"_blank\" rel=\"noopener\">Decrease in extracellular collagen crosslinking after NMR magnetic field application in skin fibroblasts &#8211; PubMed<\/a><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1faa661 e-con-full group-btn e-flex e-con e-child\" data-id=\"1faa661\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-364eb18 border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"364eb18\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4dc1fd elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"c4dc1fd\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9c2956d blue-btn elementor-widget elementor-widget-button\" data-id=\"9c2956d\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.1007\/s11517-006-0144-z\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-68bb046 e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"68bb046\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-78dc131 e-con-full accordion-summary e-flex e-con e-child\" data-id=\"78dc131\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-5a06529 pad_section e-flex e-con-boxed e-con e-child\" data-id=\"5a06529\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9516516 elementor-widget elementor-widget-heading\" data-id=\"9516516\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1bd177a elementor-widget elementor-widget-text-editor\" data-id=\"1bd177a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Although biological effects of electromagnetic fields were investigated intensively, there is still no agreement on the significance of their effects. The underlying mechanisms and therapeutic importance are still mostly unknown too. In this study, primary cultures of human dermal fibroblasts were exposed to magnetic field at nuclear magnetic resonance (NMR) conditions for in total 5 days and 4 h\/day. Among the investigated parameters were: cell proliferation rate, cell morphology, total protein concentration as well as content of skin-specific collagen types I, III, IV. NMR exposure induced distinct changes both in cellular and extracellular components. The extracellular matrix (ECM) of NMR-exposed cells had less cross-linked collagen. In particular, the increase of collagen of the soluble fraction was at 17.2 \u00b1 2.9% for type I, 27.0 \u00b1 1.86% for type III, 17.3 \u00b1 1.46% for type IV (N = 6). In the absence of resonance frequency, the effects of magnetic field on ECM were less profound.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1184c6e e-con-full accordion-wrapper e-flex e-con e-child\" data-id=\"1184c6e\" data-element_type=\"container\" id=\"last-section\">\n\t\t<div class=\"elementor-element elementor-element-d8f6f56 accordion-head e-flex e-con-boxed e-con e-child\" data-id=\"d8f6f56\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c8fdcc0 elementor-widget elementor-widget-heading\" data-id=\"c8fdcc0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2005<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6347f4e elementor-widget elementor-widget-heading\" data-id=\"6347f4e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Effects of magnetic resonance on cell proliferation <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-215d851 elementor-widget elementor-widget-text-editor\" data-id=\"215d851\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong> Temiz Artmann, P. Lindner, P. Kayser, I. Digel, G. M. Artmann &amp; P. L\u00fccker, 2005:<\/strong> NMR In Vitro Effects on Proliferation, Apoptosis, and Viability of Human Chondrocytes and Osteoblasts, Methods and Findings in Experimental and Clinical Pharmacology, 2005, 27(6), 391\u2013394<\/p><ul><li>DOI: <a href=\"https:\/\/doi.org\/10.1358\/mf.2005.27.6.896831\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">10.1358\/mf.2005.27.6.896831<\/span><\/a><\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16179956\/\" target=\"_blank\" rel=\"noopener\">NMR in vitro effects on proliferation, apoptosis, and viability of human chondrocytes and osteoblasts &#8211; PubMed<\/a><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6a0ab05 e-con-full group-btn e-flex e-con e-child\" data-id=\"6a0ab05\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e16cf35 border-btn open-accordion elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"e16cf35\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Abstract<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b24382 elementor-widget__width-initial close-accordion elementor-widget elementor-widget-button\" data-id=\"9b24382\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Quick view<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8cdd31e blue-btn elementor-widget elementor-widget-button\" data-id=\"8cdd31e\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.1358\/mf.2005.27.6.896831\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d961999 e-con-full accordion-toggle e-flex e-con e-child\" data-id=\"d961999\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-8a3d4bb e-con-full accordion-summary e-flex e-con e-child\" data-id=\"8a3d4bb\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-b3dcabc pad_section e-flex e-con-boxed e-con e-child\" data-id=\"b3dcabc\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-31dd981 elementor-widget elementor-widget-heading\" data-id=\"31dd981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b5c8c26 elementor-widget elementor-widget-text-editor\" data-id=\"b5c8c26\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>This study presents findings on the proliferation rate, cellular apoptosis, and viability of human chondrocyte and osteoblast cultures be\/ore and after treatment with NMR pulse sequences. A commercially available nuclear magnetic resonance machine (MBSI\u00ae-Nuclear Magnetic Resonance Therapy) was used for treatment. The study was carried out\/or 19 days, including 9 days of NMR exposure in a controlled, double-blind, randomized manner, using commercially available human cell lines. The study revealed that NMR treatment did not induce apoptosis or inhibit cell viability, but revealed a tendency of an elevated cell proliferation rate as observed by cell count.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65d954f elementor-widget elementor-widget-html\" data-id=\"65d954f\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<script>\r\n  jQuery(document).ready(function ($) {\r\n    $('.open-accordion').on('click', function (e) {\r\n      e.preventDefault();\r\n\r\n      \/\/ Close all open\r\n      $('.accordion-toggle').slideUp();\r\n      $('.open-accordion').show();\r\n      $('.close-accordion').hide();\r\n\r\n      \/\/ Open current one\r\n      var wrapper = $(this).closest('.accordion-wrapper');\r\n      wrapper.find('.accordion-toggle').slideDown();\r\n      $(this).hide();\r\n      wrapper.find('.close-accordion').show();\r\n    });\r\n\r\n    $('.close-accordion').on('click', function (e) {\r\n      e.preventDefault();\r\n\r\n      var wrapper = $(this).closest('.accordion-wrapper');\r\n      wrapper.find('.accordion-toggle').slideUp();\r\n      $(this).hide();\r\n      wrapper.find('.open-accordion').show();\r\n    });\r\n  });\r\n<\/script>\r\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1e245b2 pad_section e-flex e-con-boxed e-con e-parent\" data-id=\"1e245b2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3dcfb0f e-con-full e-flex e-con e-child\" data-id=\"3dcfb0f\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4111a2c elementor-absolute e-transform elementor-widget elementor-widget-image\" data-id=\"4111a2c\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_transform_translateX_effect&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:-50,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_laptop&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_tablet&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_mobile&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_laptop&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_tablet&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_mobile&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/mbst.com\/wp-content\/uploads\/elementor\/thumbs\/small-cell-1-1-ra3iuu67b1p5ekhwt0r9gzq2vaoj5joogokqs54wxq.png\" title=\"small-cell-1.png\" alt=\"small-cell-1.png\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f1d606 elementor-widget elementor-widget-html\" data-id=\"4f1d606\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"footer-nav\">\n    <a class=\"prev\" href=\"\/en\/doctor\/science\">\n        <i class=\"arrow arrow-left\">\u2190<\/i>\n      <small>previous page<\/small>\n      <span>Science & Research<\/span>\n    <\/a>\n    <a class=\"next\" href=\"\/en\/doctor\/science\/clinical-studies\">\n        <i class=\"arrow arrow-right\">\u2192<\/i>\n      <small>next page<\/small>\n      <span>Clinical studies<\/span>\n    <\/a>\n<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>MBST\u00ae Science &amp; Research Basic Research | In-vitro-studies 2025 Cellular effects of magnetic resonance Th\u00f6ni, A. Buchter, A. Flarer, J. Lampe, C. Schlegel &amp; M. 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